Józefa Wesierska-Gadek Selected Research

Cyclin-Dependent Kinases (cdk Proteins)

1/2011	Tamoxifen enhances the anti-proliferative effect of roscovitine, a selective cyclin-dependent kinase inhibitor, on human ER-positive human breast cancer cells.
1/2011	Effect of anti-estrogen combined with roscovitine, a selective CDK inhibitor, on human breast cancer cells differing in expression of ER.
8/2009	Roscovitine differentially affects asynchronously growing and synchronized human MCF-7 breast cancer cells.
8/2009	Monitoring of long-term effects of resveratrol on cell cycle progression of human HeLa cells after administration of a single dose.
8/2009	Selective cyclin-dependent kinase inhibitors discriminating between cell cycle and transcriptional kinases: future reality or utopia?
4/2009	Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment.
12/2008	Action of resveratrol alone or in combination with roscovitine, a CDK inhibitor, on cell cycle progression in human HL-60 leukemia cells.
4/2008	Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breast cancer cells.
12/2007	A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein.
10/2007	Inhibition of farnesyl protein transferase sensitizes human MCF-7 breast cancer cells to roscovitine-mediated cell cycle arrest.

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Józefa Wesierska-Gadek Research Topics

Disease

26	Neoplasms (Cancer) 01/2011 - 01/2003
15	Breast Neoplasms (Breast Cancer) 01/2011 - 09/2003
11	Carcinoma (Carcinomatosis) 05/2010 - 09/2002
4	Leukemia 01/2011 - 08/2005
4	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 05/2008 - 08/2005
3	Endotoxemia 07/2004 - 11/2003
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 04/2009 - 01/2009
1	Genomic Instability 07/2010
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 08/2009
1	Carcinogenesis 01/2007
1	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2006
1	Lung Injury 07/2004
1	Acute Lung Injury 07/2004
1	Edema (Dropsy) 11/2003

Drug/Important Bio-Agent (IBA)

16	RoscovitineIBA 01/2011 - 09/2003
13	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2011 - 01/2006
13	Proteins (Proteins, Gene)FDA Link 12/2008 - 01/2005
5	Pharmaceutical PreparationsIBA 05/2010 - 12/2006
4	EnzymesIBA 07/2010 - 11/2003
4	Cisplatin (Platino)FDA LinkGeneric 05/2008 - 01/2003
3	C 1305IBA 01/2011 - 07/2004
3	Estrogens (Estrogen)FDA Link 01/2011 - 08/2006
3	ResveratrolIBA 08/2009 - 04/2008
3	ras ProteinsIBA 05/2009 - 12/2006
3	Cytostatic AgentsIBA 12/2008 - 12/2006
2	Tamoxifen FDA LinkGeneric 01/2011 - 01/2011
2	Hormones (Hormone)IBA 01/2011 - 01/2007
2	Type II DNA Topoisomerases (Topoisomerase II)IBA 05/2010 - 07/2004
2	AntigensIBA 05/2008 - 08/2005
2	AntibodiesIBA 05/2008 - 08/2007
2	Methylnitronitrosoguanidine (MNNG)IBA 04/2008 - 08/2003
2	Alkylating AgentsIBA 04/2008 - 08/2003
2	TransferasesIBA 10/2007 - 12/2006
2	Protein Isoforms (Isoforms)IBA 08/2007 - 01/2007
2	AutoantibodiesIBA 05/2006 - 08/2005
2	Poly Adenosine Diphosphate RiboseIBA 04/2004 - 11/2003
2	Ligases (Synthetase)IBA 04/2004 - 11/2003
2	NucleotidesIBA 04/2004 - 11/2003
1	SteroidsIBA 01/2011
1	DNA (Deoxyribonucleic Acid)IBA 01/2011
1	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2011
1	Topoisomerase II InhibitorsIBA 05/2010
1	NU 1025IBA 05/2010
1	Antimitotic AgentsIBA 08/2009
1	olomoucineIBA 08/2009
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 08/2009
1	Oncogene Proteins (Oncogene Protein)IBA 08/2009
1	purineIBA 08/2009
1	PolyphenolsIBA 12/2008
1	Wheat Germ AgglutininsIBA 05/2008
1	Nuclear Pore Complex Proteins (Nucleoporins)IBA 05/2008
1	wheat germ agglutinin-sepharose 6MBIBA 05/2008
1	Phosphotransferases (Kinase)IBA 03/2007
1	Cyclin-Dependent Kinase 2IBA 03/2007
1	Caspase 3 (Caspase-3)IBA 03/2007
1	Serine (L-Serine)FDA Link 01/2007
1	SurvivinIBA 01/2007
1	Endocrine DisruptorsIBA 01/2007
1	Guanosine Triphosphate (GTP)IBA 12/2006
1	LipidsIBA 12/2006
1	Phytoestrogens (Phytoestrogen)IBA 08/2006
1	Tumor Suppressor Protein p53IBA 08/2006
1	Biomarkers (Surrogate Marker)IBA 05/2006
1	Antinuclear AntibodiesIBA 08/2005
1	Poly (ADP-Ribose) Polymerase-1IBA 01/2005
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 07/2004
1	EndotoxinsIBA 07/2004
1	NF-kappa B (NF-kB)IBA 07/2004
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 11/2003
1	3-aminobenzamideIBA 11/2003

Therapy/Procedure

12	Therapeutics 05/2010 - 09/2002
3	Drug Therapy (Chemotherapy) 03/2007 - 09/2005
1	Aftercare (After-Treatment) 08/2009
1	Drug Tapering 05/2008